Biljana DAVIDOVIĆ-PLAVŠIĆ

Associate Professor, PhD in Chemistry

Research fields: Biochemistry, Biochemistry Toxicology

Professor of Biochemistry and Doctor of Chemical Sciences in the field of biochemistry. The main goal of the research so far is based on the idea of understanding the importance of balance in the production and removal of free radicals and their role in achieving and maintaining redox homeostasis of the organism. Within national and international projects in recent years her research interest was focused on the role of free radicals in the pathophysiology of ischemic conditions and diseases. The subject of research are toxic effects caused by xenobiotics (drugs, pesticides, heavy metals) in human, animal and plant organisms as well as the role of antioxidants (plant secondary metabolites and vitamins) in protecting from various diseases and abiotic stress.

Office: Chemistry Anex
Phone: +387 51 311 178
Е-mail: biljana.davidovic-plavsic@pmf.unibl.org

Consultation: Friday 11.00-13.00

ACADEMIC CAREER
University of Banja Luka, Faculty of Natural Sciences and Mathematics
  • 2019 : Associate Professor in the field of Biochemistry and Molecular Biology
  • 2013-2019 Assistant Professor in field of Biochemistry and Molecular Biology
  • 22006-2013 Senior Assistant, University of Banja Luka, Faculty of Medicine
  • 22001-2006 Assistant, University of Banja Luka, Faculty of Medicine
  • 2000-2001 Expert Associate, Institute for Protection and Ecology Banja Luka
  • 1998-1999 Research Assistant, Institute of Nuclear Sciences„Vinča“, University of Belgrade, Serbia
COURSES
  • Biochemistry 1
  • Biochemistry 2
  • Research Methodology in Chemistry
  • Biochemical toxicology
EDUCATION
  • 2011 PhD degree in chemistry, field of biochemistry (Faculty of Natural Sciences and Mathematics, University of Banja Luka) Enzymes, early bimarkers, of gentamicin nephrotoxicity Mentor: Professor Živko Saničanin
  • 2006 Magistar of Biochemical Sciences (Faculty of Chemistry, University of Belgrade, Republic of Serbia) Effects of oxidative stress on CuZn superoxide dismutase in human blood Mentor: Professor Mihajlo Spasić
  • 1998 Bachelor degree in Biochemistry (Faculty of Chemistry, University of Belgrade, Serbia)
PROJECTS AND GRANTS
INTERNATIONAL PROJECTS
  • RoxyCOST –Oxygen sensing a novel mean for biologyand technology of fruit quality CA18210 COSTnd technology of
NATIONAL PROJECTS
  • Comparative biochemical analysis of secondary metabolites of selected medicinal plants
  • Biochemical characterization of the antioxidant capacity of phenolic compounds from selected medicinal plants from the Republic of Srpska
  • The influence of the method of isolation of biological active substances of plants on the functional activity of herbal preparations
  • The toxic effect of pesticide terbuthylazine on antioxidative enzymes and proteins of erythrocytes in vitro, coordinator
  • Influence of plant extracts on reduction of pesticide toxic effects in human erythrocytes in vitro, coordinator
  • Investigation of biochemical mechanisms of plant response to hypoxia and increased concentration of reactive oxygen species caused by floods and droughts, collaborate
SELECTED PUBLICATIONS
  • B. Kukavica, B. Davidović-Plavšić, A. Savić, D. Dmitrović, G. Šukalo, S. Đurić-Savić, G. Vučić: Oxidative Stress and Neurotoxicity of Cadmium and Zinc on Artemia franciscana Biological Trace Element Research 201(5), 2636-2649 2023. https://link.springer.com/article/10.1007/s12011-022-03352-x
  • B. Kukavica, S. Škondrić, T. Trifković, D. Mišić, U. Gašić, Lj. Topalić-Trivunović, A. Savić, A. Velimir, B. Davidović-Plavšić, M. Šešić, N. Lukić: Comparative polyphenolic profiling of five ethnomedicinal plants and their applicative potential in the treatment of type 2 diabetes. Journal of Ethnopharmacology, 320, 117377 2024. https://www.sciencedirect.com/science/article/abs/pii/S0378874123012473
  • S. Škondrić, B. Kukavica, I. Pucar, T. Trifković, J. Knežević, R. Perić, B. Davidović-Plavšić: Shaping the life in karst: Antioxidative response of two Balkan endemic Scilla species. Biochemical Systematics and Ecology, 112, 104777 2024. https://www.sciencedirect.com/science/article/abs/pii/S0305197823001941
  • B. Davidović-Plavšić, B. Kukavica, S. Škondrić, C. Jimenez-Gallardo, M. Žabić: Wild garlic extract reduces lipid peroxidation in terbuthylazine-treated human erythrocytes. Biomarkers, 26(7): 617-624 2021 https://www.tandfonline.com/doi/full/10.1080/1354750X.2021.1953598
  • B. Kukavica, B. Davidović-Plavšić, D. Dmitrović, G. Šukalo, A. Savić, V. Pešić: Seasonal Dynamics of Oxidative and Antioxidative Parameters in Sadleriana fluminensis (Gastropoda: Hydrobiidae). Malacologia 64(1): 57-67 2021 https://bioone.org/journals/malacologia/volume-64/issue-1/040.064.0102/Seasonal-Dynamics-of-Oxidative-and-Antioxidative-Parameters-in-Sadleriana-fluminensis/10.4002/040.064.0102.short
  • N. Lukić, B. Kukavica, B. Davidović-Plavšić, D. Hasanagić, J. Walter: Plant stress memory is linked to high levels of anti-oxidative enzymes over several weeks. Environmental and Experimental Botany, 178: 104166 2020. https://doi.org/10.1016/j.envexpbot.2020.104166
  • B. Davidović-Plavšić, N. Lukić, A. Nikolić-Kokić, B. Kukavica: Effects of hemazin SC 500 (terbuthylazine) on antioxidative enzymes in human erythrocytes in vitro. Journal of the Serbian Chemical Society 84:455-465 2019 https://doi.org/10.2298/JSC181011115D
  • T. Vujić, S. Uletilović, J. Predojević-Samardžić, B. Davidović-Plavšić, S. Stoisavljević-Šatara Ž. Saničanin: The activity of proximal tubule enzymes in the urine of cephalexin-treated patients. Journal of Medical Biochemistry 30:131-134 2011 https://doi: 10.2478/v10011-011-0005-7
  • B. Davidović-Plavšić, T. Vujić, S. Uletilović, J. Predojević-Samardžić, D. Malčić, Ž. Saničanin: Urinary activities of proximal tubule enzymes in neonates treated with gentamicin. Journal of Medical Biochemistry 29:44-47 2010 https://doi.org/10.2478/v10011-010-0002-2
  • A. Nikolić-Kokić, Z. Stević, D. Blagojević, B. Davidović, D. R. Jones, M. B. Spasić; Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. Clinical Chemistry and Laboratory Medicine 44:589-593 2006 https://doi.org/10.1515/CCLM.2006.111
OTHER
  • Mentor for second cycle of studies at the Faculty of Natural Sciences and Mathematics, University of Banja Luka
  • Mentor for third cycle of studies at the Faculty of Natural Sciences and Mathematics, University of Banja Luka
  • Cooperation with the Institute for Biological Research “Siniša Stanković”, University of Belgrade, Serbia
  • Cooperation with the Faculty of Sciences in Novi Sad, University of Novi Sad, Serbia
  • The reviewer in national and international journals

Chemistry Department

ПМФ | М. Стојановића 2, Бања Лука